Penicillin was the first known effective treatment medication for syphilis. Up to now, it is still used to battle this sexually-transmitted disease as it continues to prove that is can effectively get rid of the bacterium.

People who have undergone syphilis testing and treatment are usually prescribed by doctors with the following treatment medications:

- Those who are suffering from primary or secondary syphilis are given the following meds and doses:

one dose of Benzathine penicillin G 2.4 million units intramuscularly (IM) taken

- Those who are in the early latent syphilis stage are given:

a single dose of Benzathine penicillin G 2.4 million units also taken intramuscularly

- People who are in the latent stage of syphilis are given:

three doses of 2.4 million units IM of Benzathine penicillin G for a total of 7.2 million units total, with a one-week interval between each dose

- Pregnant women with syphilis are also given penicillin.

- People with syphilis who turn out to be allergic to penicillin undergo a skin test to desensitive them. They are then prescribed other antibiotic treatment meds by their doctors to fight off the syphilis infection.